Now It's Time to Say Goodbye by Dale Peck

When the 500th person they know dies of AIDS, Colin and Justin flee New York City. They end up in Galatia, a Kansas town founded by freed slaves in the wake of the Civil War whose population is now divided, evenly but uneasily, between African Americans descended from the town’s founders and Caucasians who buy up more of the town’s land with each passing year. But within weeks of relocating, they are implicated in a harrowing crime, and discover that they can’t outrun their own tortured history, nor that of their new home. An encompassing, visionary, many-threaded work, Now It’s Time to Say Goodbye is an American novel of great scope and nearly mythological intensity.

This is the third volume of Gospel Harmonies, a series of seven stand-alone books (four have been written) that follow the character of John in various guises as he attempts to navigate the uneasy relationship between the self and the postmodern world.